ماذا تعرف عن دوااااااااااااااااااااااا ااء نيكسافار؟؟؟

[ayia]

What is sorafenib(Nexavar)?
Dosage form tab.200mg
Indication

for the treatment of advanced renal cell carcinoma when treatment with interferon alfa or interleukin-2 has failed or is contra-indicated……
for the treatment of hepatocellular carcinoma………
What is sorafenib
Sorafenib is a type of biological therapy called a protein tyrosine kinase inhibitor (TKI) .Tyrosine kinase is a protein which acts as a chemical messenger (an enzyme). There are a number of different tyrosine kinases that encourage cancer cells to grow.Sorafenib blocks a number of protein kinases and is called a multi kinase inhibitor.
It works in two ways.
**It stopsSignals that tell cancer cells to grow
**Cancel cells forming blood vessels, which they need to grow,Treatment that stops blood vessels forming is called anti angiogenesis treatment
Dose
Sorafenib is a tablet take with a glass of water.It should take either an hr before eat or 2 hrs after.
ADULT over 18 years, 400 mg twice daily
Interaction
*Antibacterial:plasma conc. of sorafenib reduced by rifampicin
*Anticoagulants:sorafenib possibly enhances anticoagulant effect of coumarins
*Antiepileptics:cytotoxics possibly reduce absorptionof phenytoin
*Antipsychotics:avoid concomitant use of cytotoxicswith clozapine (increased risk of agranulocytosis

*Cardiac Glycosides:cytotoxics reduce absorption of digoxin tablets

*Cytotoxics: sorafenib possibly increases plasma conc.of doxorubicin and irinotecan, increases plasma concentration of docetaxel

Pharmacokinetic data
1-Bioavailability 29-49%

2-Protein binding 99,5%

3-Metabolism,Hepatic oxidation and glucuronidation (CYP3A4 mediated)

4-Half life 25-48hours

5-Excretion Fecal (77%) and renal (19%)

Side effect

Common side effects

**Diarrhoea **Hand-foot syndrome

**rash, or red, dry itchy skin **Fatigue

Hair thinning **Feeling sick **Raised blood pressure (hypertension) **Increased risk of bleeding


Rare side effects

**Breast tenderness and swelling because sorafenib may lower male sex hormone (testosterone) levels

**Heart problems including chest pain

**Bleeding of the stomach lining occurs in less than (1%)

With this drug, some people have a temporary drop in the number of blood cells made by the bone marrow, leading to the following side effects

**Increased risk of getting an infection from a drop in WBC

**Tiredness and breathlessness due to a drop in RBC

**Bruising more easily due to a drop in platelets

Some of these side effects can be life threatening, particularly infections

Other occasional side effects include

Skin flushing, Aching joints, Constipation

, sore mouth, Indigestion, WeaknessPain

Loss of appetite, Flu like symptoms

A hoarse voice, Low mood

A mild effect on the liver

[Dr-Mohammed_714s]

موضوع قيم د/أيه
--------------------
هو فعلاً غقار النيكسافار من الأدوية الحديثة ومن أوائل الأدوية التى تم أعتمادها فى علاج أورام الكبد مثل Hepatocellular Carcinoma بالأضافة لأستخدامه فى Renal Cell Carcinoma
وأليه عمل العقار كمات ذكرتى
Tyrosine Kinase inhibitor ==> Inhibit signal transduction pathway ===> Inhibit tumor growth
وهذا ببساطة شديدة جداً
ولا يعتبر العقار جديداً فى أليه عمله فقد سبقة الكثير من الغقاقير الأخرى التى تنضم فى نفس المجموعة
ولكن سعر العقار مرتفع جدا
كما أن تأثيره بشكل عام لا يمثل Treatment بالمعنى الحرفى للكلمه ولكنه يعتمد على منع تطور وتدهور المرض والحد من بعض أعراضه ولذلك لا يضع كثيرا من أطباء الأورام أمالهم عليه للعلاج الكامل مما قيد من أستخدامه فى مصر

[ayia]

مشكور دكتور محمد على ردك وتعليقك فعلا ان سعره مرتفع جدا وهذا احدى الاسباب صراحة الي دفعتني كصيدلانية سريريةوطلب مني من قبل الطبيب المعالج لاحدى المريضات بان ابحث عنه بطريقة مفصلة

[dr/mahmoud zayed]

شكرا علي المعلومات القيمة دي بس كنت عاوز اعرف سعره كام؟؟؟